Deadpool is an action hack and slash, third-person shooter video game. Gameplay mostly consists of fighting enemies using both melee weapons and guns, with new combos becoming available to Deadpool as he progresses through the story and obtains upgrade points. The game frequently breaks the fourth wall by having Deadpool verbally interact with the player based on their skill and progress.

By default, Deadpool is armed with both guns and swords, but he also has access to giant hammers, plasma guns, and a range of other weapons. A short range of teleportation moves are possible as well. As he slowly falls apart while sustaining damage, players must avoid further damage in order to recover. The game also features several stealth segments, where Deadpool is able to eliminate enemies silently with either his melee weapons or guns, though gun “stealth” kills will immediately alert all nearby enemies.